Below are selected publications in context with our drug discovery research from among our Research and Development and Scientific Advisory Board teams.

Tóth, G., Neumann, T., Berthet, A. et al. (2019),  Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. Sci Rep 9, 16947. doi:10.1038/s41598-019-52598-4

Solti, K., Kuan, W.-L., Fórizs, B., Kustos, G., Mihály, J., Varga, Z., … Tóth, G. (2020), DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits. Neurobiology of Disease134, 104629. doi: 10.1016/j.nbd.2019.104629

Kiss R., Csizmadia G., Solti K., Keresztes A., Zhu M., Pickhardt M., Mandelkow M., Tóth G., Structural Basis of Small Molecule Targetability of Monomeric Tau Protein, ACS Chem Neurosci., Article ASAP, 2018, doi: 10.1021/acschemneuro.8b00182

Kiss R., Zhu M., Jójárt B., Czajlik A., Solti K., Fórizs B., Nagy É., Zsila F., Beke-Somfai T., Tóth G. "Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease." Biochim Biophys Acta. 2017, 1861, 2619-2629. doi: 10.1016/j.bbagen.2017.08.017

Fisher E., Zhao Y., Richardson R., Janik M., Buell A.K., Aigbirhio F., Tóth G. "Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis." ACS Chem Neurosci. 2017, 20, 2088-2095. doi: 10.1021/acschemneuro.7b00228

Pickhardt M., Neumann T., Schwizer D., Callaway K., Vendruscolo M., Schenk D., St. George-Hyslop P., Mandelkow E., Dobson C. M., McConlogue L., Mandelkow E. and Toth G. "Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies." Current Alzheimer Research, 2015, 12(9): 814 - 828

Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L (2014), "Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease." PLoS One 9(2):e87133

Zhu M, De Simone A, Schenk D, Toth G, Dobson CM, Vendruscolo M (2013), "Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide." Journal of Chemical Physics 139(3):035101

Madian AG, Hindupur J, Hulleman JD, Diaz-Maldonado N, Mishra VR, Guigard E, Kay CM, Rochet JC, Regnier FE., "Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1. Mol Cell Proteomics." 2012 Feb;11(2):M111.010892.

Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G (2009), "On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid." Biochemistry 48(35):8322-34

Buell AK, Esbjörner EK, Riss PJ, White DA, Aigbirhio FI, Toth G, Welland ME, Dobson CM, Knowles TP (2011), "Probing small molecule binding to amyloid fibrils." Phys Chem Chem Phys 13(45):20044-52

Liu F1, Nguyen JL, Hulleman JD, Li L, Rochet JC., "Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease." Journal of Neurochemistry, 2008 1;105, 2435-53

Hulleman JD, Mirzaei H, Guigard E, Taylor KL, Ray SS, Kay CM, Regnier FE, Rochet JC., "Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease." Biochemistry. 2007 May 15;46(19):5776-89