Cantabio Pharmaceuticals to Present Update from Its DJ-1 Protein Targeting Therapeutic Program for the Treatment of Parkinson's Disease at Advances in Alzheimer's and Parkinson's Therapies, An AAT-AD/PD Focus Meeting in Torino, Italy
SAN FRANCISCO, CA -- (Marketwired) -- 01/22/18 -- Cantabio Pharmaceuticals Inc. (OTCQB: CTBO), a biopharmaceutical company developing novel disease modifying therapies for Alzheimer's, Parkinson's and other related neurodegenerative diseases, today announced that Dr. Gergely Toth, Cantabio's CEO, will present results of the company's DJ-1 protein targeting small molecule pharmacological chaperone therapeutic program at the Advances in Alzheimer's and Parkinson's Therapies, An AAT-AD/PD Focus Meeting in Torino, Italy, March 15 - 18, 2018.
Loss of DJ-1 protein function has been linked to the onset of a variety of diseases, such as Parkinson's disease, Alzheimer's disease, stroke, amyotrophic lateral sclerosis, chronic obstructive pulmonary disease and type II diabetes. The DJ-1 protein is considered to be one of the primary therapeutic targets for Parkinson's disease, as it is genetically linked to the onset of familial Parkinson's disease.
The presentations will describe the positive biological activity in cellular and in vivo models of Parkinson's disease of Cantabio's novel DJ-1 protein targeting small molecule drug candidates and novel findings relating to the mechanism of loss of function of DJ-1 in disease conditions.
The data will be presented on:
March 18, 8:50-9:10 CET - Symposium 27 - Emerging Treatments in PD; Abstract Number AAT18-0226
The lecture is titled, "Identification and optimization of a novel DJ-1 targeting small molecule with protective activity in Parkinson's disease relevant cellular and in vivo models".
March 17, 8:00-18:00 CET -- C01.b. C1.b Disease Mechanisms, Pathophysiology: LRKK2, parkin, PINK1, DJ-1; Abstract Number 145
The poster is titled, "DJ-1 protein aggregates into b-sheeted oligomers and fibrillar aggregates which results in loss of its native functions".
The presentations are co-authored by researchers from Purdue University (USA), Novalix SAS (France), University of Antioquia (Colombia), and the Hungarian Academy of Sciences.
Cantabio's CEO, Dr. Gergely Toth said: "We are excited to share an update on the positive progress of our DJ-1 protein targeting pharmacological chaperone program at this major conference, as well as new insights into the mechanism of loss of function of DJ-1 during disease onset and progression. These results from our in-house and collaborators' research demonstrate our growing confidence in our DJ-1 targeting therapeutic candidates' excellent potential as disease modifying therapeutics for PD and AD."
Cantabio is focused on bringing novel, first in class drug candidates into clinical trials and beyond through the discovery and development of innovative pharmacological chaperone and protein delivery based therapeutics, focusing on protein systems implicated in neurodegenerative disorders, including Alzheimer's, Parkinson's and oxidative stress. More information is available at www.cantabio.com.
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Source: Cantabio Pharmaceuticals Inc.
Released January 22, 2018